The Center for Reproductive Health at the University of California, San Francisco and the Reproductive Medicine Network are researching the effects of lifestyle modifications in obese women with unexplained infertility.

Volunteers are needed for this study.

Women who are overweight (with a BMI greater than 30), are 18-40 years old with regular menstrual periods, have had infertility for more than one year, and who seek pregnancy may be eligible participate.

In the first phase of the study, lasting 16 weeks, participants will do one of two lifestyle changes. One group will increase their physical activity by increasing steps per day using a FitBit fitness watch.

The other group will adhere to a calorie restricted diet using Nutrisystem meal replacements and a weight loss medication called Orlistat (Alli) while increasing physical activity using a FitBit. The second phase of the study includes infertility medications and insemination.

Participation in the study requires office visits at 499 Illinois Street, San Francisco, taking the study medication, wearing a Fitbit, using Nutrisystem meals, keeping a diary, and undergo a physical exam, blood work, tests to determine if the fallopian tubes are open (with a semen analysis from partner) and intrauterine inseminations.

For more information, call 415-885-3598 or visit www.ivf.ucsf.edu and click on Research.