Science has shown that female and male brains are different as well as Transgender brains. Transgender women (assigned male at birth (born with a dick)) have brains that are almost like that of a woman's from birth. The same can be said about Transgender men (born with a uterus). It has been found that severe trauma can alter the gender structure of the brain. The theoretical cause fir Transgenderism is based on the gentiles forming in the womb before the regions of the brain that differ between genders by 5 months and a large change in the hormones within that 5 month period causes it.

Historically Transgender people have been around as long as recorded history and farther back. In many cultures and religions throughout history they were accepted until the rise of certain faiths and the fall of many nations

https://www.scientificamerican.com/article/is-there-something-unique-about-the-transgender-brain/

http://sitn.hms.harvard.edu/flash/2016/gender-lines-science-transgender-identity/

http://transascity.org/the-transgender-brain/