1 year old screaming at night?

Rachel

This is harder than the colic days! Not sure what it is or why, but my 1 year old has been screaming right before bed time. She's also been waking up crying and screaming a bunch of times during the night and I cannot calm her down. She's already had baby Motrin for the teething (looks like the back teeth are coming in) and doesn't want a bottle or to even be held. Thoughts?