My wife is nearly 8 weeks pregnant and last week during our first ultrasound we heard a loud healthy heart beat (141) and CRL was 10.24. We left the office extremely excited. A couple hours later we got a call from the office that her progesterone was lower the then previous two blood tests (13). They suggested she start vaginal progesterone to hopefully prevent a miscarriage and continue it until week 13 when placenta takes over. She’s been on it for 4 days and her personality has completely changed. She’s extremely moody, depressed and crying over anything and everything. Is anyone on this medication? Is this normal? She’ll have to continue taking it for the next 5 weeks.