Zofran doesn't work anymore :(

Kayla
I'm so damn sick. I literally can not live a functioning life right now. I've lost 10lbs in the past 3 weeks. Zofran no longer works.. I take it in the morning and throw up like 45mins later. Is anyone out there on a different prescription medication for nausea? I need some input.. I'll be calling my dr this afternoon, but would love some first hand advice! 
Please.. Please.. Please.. Save all the "just eat small meals, protein, crackers before your feet touch the floor.." I've tried everything. I've also tried B6 with Unisom.. No relief. I'm afraid I might end up back in the ER for dehydration/lack of nutrition :(