Moving with my cat!

Hey ladies, I’m moving from western PA, to Maine. It’s going to be about a 16 hour car ride which we plan on doing over 2 days. My car hates the car (gets really anxious) and I’ve already gotten some sedative for her (not going to knock her out just give her enough to calm down) from the vet because I don’t want to stress her out too much. But does anyone have suggestions on how to make this stress free as possible for her? I’m so worried about it because I know moving will be stressful for us and she’ll pick up on that, and also she’ll be moving to our new home with us so it’s going to be a whole new place. And on top of that the holidays come right after we move and we plan on taking her with us because we don’t know anyone where we are moving. Any suggestions please! I just want to make sure I don’t stress her out to high heaven!