Any medicine to calm toddler down?

Going on a really long flight. my 2 year old is extremely active and has a hard time sitting and staying in one spot. When aggravated he tends to scream. Any over the counter medicine to calm him down maybe get him to sleep as well? Is Benadryl something to consider?

***Edit***

Thank you to the people who actually gave advice i did learn a lot.

I asked about Benadryl because my friend (who is not a mom) told me her mom used to give it to her when she wouldn’t calm down.

Being a first time mom and don’t have any mommy friends i don’t know these things, thats why i use glow for help but most of your answers are just rude and telling me to go get help? Isn’t that what am doing?

Like any parent I would never do anything to harm my child, thats why i ask questions.

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