Help!

The first couple weeks my daughter was so laid back and slept great. Then things started going downhill. She would scream her head off and throw up every meal even being held upright for 30 mins. The doctor out jer on reflux meds and that worked for a few days. I had a calm, smiley baby. Now yesterday and today we are back to screaming like she is in pain off and on all day but has been screaming all evening/night. I am losing my mind. It is ripping out my heart that I don't know how to help her. Any ideas?!?!