Mentally uncomfortable?

So I’ve been on medication for depression and anxiety for years and I’ve always noticed this thing that happens to me. I’ll go the entire day feeling completely fine or even be in a great mood, and then at some point I just feel...uncomfortable. It’s not like I’m having horrible thoughts or anything to cause it, I just simply get really uncomfortable. They come in waves. Sometimes i won’t have one for weeks and other times it happens everyday. I never know what to do or how to help it go away and I guess I was just wondering if this happens to anyone else. Tips would be greatly appreciated also 💙